What Is Dapoxetine?
Generic dapoxetine is a premature ejaculation (PE) medicine which was initially developed as an antidepressant. In fact, the preparation is a representative of SSRI family antidepressants typically belong to. However, dapoxetine can’t be called one due to such properties as quick absorption into the bloodstream and fast elimination from the body. All in all, a fast acting property makes the preparation discussed different from typical members of SSRI family.
What Is Mechanism of Dapoxetine Action?
It may be interesting for you to get familiar with the way dapoxetine works in the human body before you buy dapoxetine for treating PE.
To begin with, it should be noted that the mechanism of dapoxetine action is not completely clear. Scientists suppose that it is based on inhibiting serotonin transporter and further causing the increase in serotonin action.
Speaking of the ejaculation mechanism, the central nervous system is the major regulator of human ejaculation. To understand where the medicine works let’s trace the whole pathway that in the end leads to ejaculation. The starting point is the thoracolumbar and lumbosacral level of spinal cord where spinal reflex occurs due to stimuli from male genital. The brain stem then receives these signals which are after that affected by such nuclei as medial preoptic and paraventricular nulcei. Dapoxetine gets into gear at the supraspinal level where ejaculatory expulsion reflex is inhibited. Lateral paragigantocellular nucleus (LPGi) neurons are modulated in a certain way at that point. Such a modulation causes PMRD (pudendal motoneuron reflex discharge) latency to increase. It is still unknown whether dapoxetine has direct influence on LPGi neurons or affects these structures somehow indirectly.
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What Precautions Should I Take Before Getting Started with Dapoxetine?
Before you purchase dapoxetine keep in mind that the medicine is available on a doctor’s prescription only. That means that you should first see your doctor to have a discussion on whether you can safely take dapoxetine or not.
What Are Dapoxetine-Related Contraindications?
Before you acquire dapoxetine, you should know the list of contraindications related to the use of dapoxetine. A drug is contraindicated when there are possible health threats connected with the use of this medicine. That is why it is vitally important to find out the list of contraindications from your doctor prior to ordering dapoxetine online.
Dapoxetine is strictly contraindicated if you:
• have an allergy to dapoxetine or any ingredient of the medicine;
• suffer from hepatic impairment;
• have been to
• take such CYP3A4 inhibitors as ritonavir, ketoconazole, and telithromycine.
Dapoxetine may be contraindicated based on your doctor’s decision if you:
• have such heart problems as heart failure, ischemic heart disease, etc;
• have a pacemaker;
• take thioridazine, serotonin-norepinephrine reuptake inhibitors, SSRIs, monoamine oxidase inhibitors, or tricyclic antidepressant.
After you stop taking any of these medications, you will need to take a 14-day pause before you are able to take dapoxetine. You should also bear in mind that after you stop taking dapoxetine it is necessary to wait for 7 days before getting started with any of the above-mentioned medicines.
What Else Should I Tell My Doctor?
To help your doctor make a right decision about your ability to take dapoxetine you should also tell your doctor if you:
• have or have recently had any condition (some may affect the clinical course in a negative way);
• are taking any medicines whether over-the-counter or given out on prescription (some of them may turn out to interact with dapoxetine);
• have an allergy to any foods, herbals, and other substances.
The more details you report to your doctors, the safer your treatment will be. It is important to understand this before you buy dapoxetine online.
How Should I Take Dapoxetine?
Dapoxetine belongs to the category of prescription drugs. You need to be given out a dapoxetine prescription before beginning treatment. The prescription paper is issued by doctor based on the information you’ve provided. It should include detailed guidelines concerning your personal schedule, dosing and duration of treatment. It is important that you closely follow these guidelines throughout the entire course of treatment. You shouldn’t change your prescribed dose or schedule by yourself, or take the medicine for a shorter or longer period of time than is prescribed. It’s your doctor who can determine these points or make adjustments, if necessary. It is strongly recommended that you seek your doctor’s advice before taking your own measures.
Common recommendations about the use of dapoxetine are presented below.
1. Dapoxetine is taken by mouth.
2. It is important to take dapoxetine with plenty of water.
3. The best effect is achieved if dapoxetine is taken about an hour prior to sexual intercourse.
4. Taking more medicine than prescribed is inadmissible in connection with the risk of an overdose. Do not take more than one prescribed dose a day.
What Is My Dose?
Before you purchase dapoxetine online, you should determine on the dose that is suitable for you. Your doctor will help you with that.
Dapoxetine is available in a few dosing options: 30, 60 and 90 mg. The starting dose recommended by specialists is an average one – 60 mg. Starting with this will soon show whether the medicine works the way it is supposed to or not. If not, you can increase the dose with the permission if your doctor.
The medicine comes in different packages: 10, 30, 90 and 120 pills. If you want to use the medicine on a permanent basis, it is most beneficial to buy the 120 pills package.
Where Can I Buy Dapoxetine?
Dapoxetine is a prescription medicine that can be bought from our dapoxetine online pharmacy. You can fill out an order form while sitting on your comfortable chair. Do you utterly need a medicine? We have a solution for you. All you need to do is to make a few mouse clicks. Your geographical position makes no difference. No matter which hemisphere you live in – you can buy dapoxetine online Canada, or you can buy dapoxetine online Australia. The Internet has helped get rid of all boundaries. That means that you can freely buy dapoxetine online UK, or wherever you live.
What Are Side Effects of Dapoxetine?
It is recommended that you get familiar with the list of possible side effects associated with the use of dapoxetine.
Like any other medication, dapoxetine may cause either mild or serious adverse effects depending on the trigger factor. People themselves are often responsible for side effects because they often don’t observe elementary rules. For example, abuse of an active substance may result in dangerous overdose symptoms that can present danger to the person’s health. In such a case, it is extremely important to react to the situation at once and seek emergency medical attention immediately. However, in the majority of cases patients develop mild side effects which don’t require any medical assistance. Mild adverse effects disappear by themselves some time later.
Mild side effects of dapoxetine may include:
• dry mouth.
The following side effects may occur for different reasons including abuse or misinterpretation of your doctor’s prescription:
• symptoms of a severe allergic reaction (skin rash, itching, difficulty breathing, swelling);
The above-mentioned lists have no pretensions of being complete. Ask the medical specialist for full detailed information.
It should also be mentioned that dapoxetine rarely causes erectile dysfunction as a side effect compared to antidepressants from the same SSRI group. Researches showed that libido is mildly affected by such an active substance as dapoxetine.
Does Dapoxetine Have Drug Interactions with Such ED Preparations As Viagra or Cialis?
Premature ejaculation is often accompanied by erectile dysfunction (ED) in many male patients. That is why people who take dapoxetine may need to take ED medicines (like Viagra or Cialis) too to provide a full-fledged sexual intercourse. The studies showed that dapoxetine doesn’t affect the action of tadalafil or sildenafil, active substances of popular ED preparations.
There is no significant interaction in case of intake of alcohol either.
However, it is strongly recommended that you check with your doctor to tell him what medicines you are currently taking before you start treatment with dapoxetine.
What Is Premature Ejaculation
The premature ejaculation (PE) problem is related to the sexual sphere. The problem consists in extremely fast ejaculation that follows almost immediately after the beginning of sexual intercourse. According to the definition by experts at the International Society for Sexual Medicine, the adjective “premature” means that a person reaches orgasm within approximately one minute. However, according to another reliable source, a person experiences orgasm within only 15 seconds. No matter how many seconds should pass for the problem to be called premature ejaculation, one thing remains obvious – it takes an afflicted person very little time to finish sexual intercourse.
Men with the PE problem have 1 minute ejaculatory latency whereas the typical index is 4-8 minutes. Afflicted men say that they seem to have little control over ejaculation. So, it is difficult for them to prolong sexual intercourse.
In connection with embarrassment men experience as a result of fast sex, they often have emotional and relationship distress. On the contrary, women’s attitude to the problem is much more indulgent.
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